BCBS SC Provider Enrollment in 2026: The Complete South Carolina Blues Guide to MyPEP 2.0, BlueChoice HealthPlan, CBA Behavioral Health Credentialing, Healthy Blue SC Medicaid, and Every 2026 Update S

Everything South Carolina healthcare providers need about enrolling with BlueCross BlueShield of South Carolina -- including why MyPEP 2.0 launched April 4, 2022 and upgraded June 2025 is the only accepted enrollment pathway, why behavioral health credentialing routes through CBA and not MyPEP, why Avalon manages lab benefits independently from the enrollment process, and what the 21-day missing-item cancellation clock means for every application in progress right now.

BCBS SC provider enrollment is the process through which South Carolina healthcare providers join the BlueCross BlueShield of South Carolina network by logging into MyPEP (My Provider Enrollment Portal) 2.0 at bluecross-sc.my.site.com using Google Chrome, selecting the correct application type for their provider category, submitting a clean application with all required documentation including initials and date on every page, completing the CAQH ProView profile with current attestation, responding to any missing-item notifications within 21 days before the application is canceled, e-signing agreements through Adobe Acrobat Sign using signature type "Type" not "Image," and receiving a welcome notification with their network effective date after the credentialing committee approves.

BlueCross BlueShield of South Carolina is an independent mutual insurance company -- not owned by GuideWell, not owned by HCSC, and not owned by Elevance Health.

It has covered South Carolinians since 1946, serves over one million South Carolina members, and is the largest health insurer in the state.

Avalon is an independent company that manages lab benefits on behalf of BlueCross BlueShield of South Carolina -- a named operational entity providers encounter during network participation that no independent guide has ever explained.

bcbs south carolina provider enrollment covers four distinct product entities under one independent mutual structure.

This guide covers nine 2026 updates every South Carolina provider must know: MyPEP 2.0 launched April 4, 2022 and upgraded June 2025 with a revised January 2026 User Manual, the Adobe Acrobat Sign "Type vs.

Image" signature requirement that returns incorrectly signed agreements for correction, the 21-day missing-item cancellation clock that restarts the entire 60-to-90-day credentialing timeline if missed, the 90-day CAA directory validation through M.D.

Checkup inside My Insurance Manager, behavioral health credentialing through CBA (Companion Benefit Alternatives) rather than MyPEP, and four additional policy updates affecting South Carolina provider revenue in 2026.

MedSole RCM manages every step of bcbs sc provider enrollment across all 50 states -- from MyPEP 2.0 application type selection and CAQH ProView completeness verification through the 21-day missing-item clock, Adobe Acrobat Sign e-signature coordination, CBA behavioral health routing, and Healthy Blue SC Medicaid ID NPI assignment -- at $99 per payer with a 99 percent first-time approval rate.

Our provider enrollment and credentialing services cover BlueCross BlueShield of South Carolina commercial, BlueChoice HealthPlan HMO, and Healthy Blue SC Medicaid under one coordinated South Carolina workflow.

Who Is BCBS SC in 2026: Four Entities, One Independent Mutual Company, Avalon for Lab Benefits, FEP Administration, and South Carolina's Military Population

BlueCross BlueShield of South Carolina is an independent mutual insurance company established in 1946 -- not owned by GuideWell, not owned by Health Care Service Corporation, and not owned by Elevance Health -- and operates four distinct health coverage entities in South Carolina: BlueCross BlueShield of South Carolina for commercial PPO and EPO products, BlueChoice HealthPlan of South Carolina for HMO coverage, Healthy Blue SC for Medicaid managed care through South Carolina Healthy Connections, and BlueCross Medicare Advantage through scbluesmedadvantage.com for the state's Medicare population.

Each entity requires separate credentialing. The commercial BlueCross track covers physicians and group practices; the other three entities each require distinct applications.

Four Distinct Entities -- Enrolling With One Does Not Cover the Others

The four BCBS SC entities are legally distinct and operationally separate. A provider who credentials with BlueCross BlueShield of South Carolina commercial products cannot bill BlueChoice HealthPlan HMO patients until a separate BlueChoice credentialing is completed.

A provider who completes commercial BlueCross credentialing cannot bill Healthy Blue SC Medicaid patients without completing the Medicaid ID NPI assignment through SCDHHS and the separate Healthy Blue SC enrollment through MyPEP.

South Carolina providers who credential with only one BCBS SC entity are generating out-of-network claims for patients covered by the other three entities without knowing why those claims are denying.

See Join Our Networks -- BlueCross BlueShield of South Carolina and BlueChoice HealthPlan, MyPEP 2.0 for the official four-entity enrollment confirmation. The bcbs of sc state health plan for state employees operates through a separate Select Health track covered in Section 8.

Avalon -- Independent Lab Benefits Manager for BCBS SC

Avalon is an independent company that manages lab benefits on behalf of BlueCross BlueShield of South Carolina -- meaning laboratory service providers and providers who order lab work for BCBS SC patients interact with Avalon separately from the standard BCBS SC credentialing process, and Avalon's involvement in lab benefit authorization and reimbursement is completely independent from MyPEP and standard provider credentialing.

Zero independent source has ever named Avalon for BCBS SC. MedSole's guide is the first indexed independent article to explain Avalon's function for South Carolina providers. When lab-related claims behave differently from standard BCBS SC medical claims, Avalon's separate authorization system is the operational reason.

FEP Administration and South Carolina's Military Population

BlueCross BlueShield of South Carolina administers the Federal Employee Program (FEP) for South Carolina's federal government employees, military retirees, and their dependents -- and South Carolina's military concentration makes FEP one of the most significant provider enrollment considerations in the state, with Fort Jackson (the largest US Army basic training installation in the country), Joint Base Charleston, Marine Corps Air Station Beaufort, Marine Corps Recruit Depot Parris Island, and Shaw Air Force Base all generating substantial FEP and TRICARE patient volume.

South Carolina providers serving both TRICARE military members and BCBS SC commercial patients are managing two completely separate enrollment systems with no shared infrastructure. Our TRICARE credentialing guide covers the complete TRICARE enrollment pathway for South Carolina providers -- TRICARE and BCBS SC operate entirely separate credentialing processes.

BlueCross Medicare Advantage -- operating through scbluesmedadvantage.com as the only Medicare Advantage provider based in South Carolina -- requires active CMS Medicare enrollment through PECOS as a federal prerequisite.

Our Medicare provider enrollment guide covers the PECOS enrollment prerequisite and the specific BlueCross Medicare Advantage plan suite available across South Carolina's Upstate, Midlands-Coastal, and Lowcountry regions.

Nine 2026 BCBS SC Updates Every South Carolina Provider Must Know Before Submitting a Single Enrollment Document

As of May 2026, nine material changes to BlueCross BlueShield of South Carolina's provider enrollment architecture, portal system, credentialing process, and ongoing compliance requirements directly affect South Carolina provider revenue -- and the most operationally significant of these is that MyPEP 2.0 replaced every previous fax-and-email enrollment pathway as of April 4, 2022 and upgraded to its current version in June 2025 with a revised January 2026 User Manual that governs every enrollment application submitted today.

Update 1 -- April 4, 2022: MyPEP Launched -- The New Provider Enrollment Process

On April 4, 2022, BlueCross BlueShield of South Carolina implemented My Provider Enrollment Portal (MyPEP) as its official provider enrollment tool -- replacing previous fax and email submission pathways -- and any provider using pre-2022 enrollment guidance, fax submission procedures, or older application forms is using a deprecated process that is no longer accepted by BCBS SC's enrollment team.

The April 4, 2022 -- BlueCross BlueShield of South Carolina implemented My Provider Enrollment Portal (MyPEP) announcement is the only indexed source naming this implementation date. MedSole is the first independent source to cite it.

A South Carolina provider who submits enrollment documents by fax or email without using MyPEP is submitting through a deprecated channel -- BCBS SC won't process the application through the pre-2022 workflow, and the provider must restart through MyPEP before any credentialing review begins.

The current enrollment manual is the January 2026 MyPEP 2.0 User Manual, not any pre-2022 documentation.

Update 2 -- June 2025: MyPEP 2.0 Upgrade with January 2026 User Manual

MyPEP upgraded to its current version, MyPEP 2.0, in June 2025 -- and the MyPEP 2.0 User Manual -- Revised January 2026 -- application types, statuses, and e-sign workflow was revised January 2026, covering all current application types, required uploads, portal status labels, and the e-sign workflow through Adobe Acrobat Sign -- making any enrollment guide published before June 2025 structurally outdated for the current BCBS SC enrollment process.

The MyPEP 2.0 system handles medical, behavioral health, dental, and virtual care enrollment under one portal.

Providers who enrolled before June 2025 using the original MyPEP version should confirm their portal access is current for MyPEP 2.0 -- the June 2025 upgrade may have changed navigation paths for maintenance requests.

Educational Videos for MyPEP 2.0 are available on the Provider Enrollment Checklists and Videos page at southcarolinablues.com -- the only official BCBS SC video training resource for the current portal version.

Update 3 -- 2026: Adobe Acrobat Sign E-Signature Requirement -- Type vs. Image

BCBS SC's e-sign workflow in MyPEP 2.0 routes agreements through Adobe Acrobat Sign -- and providers must use signature type "Type" (not "Image") when signing, because "Image" signatures lack the required date and time stamp that BCBS SC's system requires, and "Image" signatures are returned for correction which adds processing time to every application they affect.

BCBS SC explicitly warns providers not to treat Adobe Acrobat Sign emails as spam -- allow emails from the @bcbssc.com domain through all spam filters before the e-sign email is expected.

Correct email addresses entered in MyPEP for the practitioner, credentialing contact, and fiduciary contact fields determine where the signature requests route.

A single incorrect email address in MyPEP's signer fields delays the entire e-sign workflow -- the signature request routes to the wrong recipient, the application sits in "Awaiting Signature" status indefinitely, and the 21-day missing-item clock runs simultaneously.

This is the most operationally granular enrollment fact in MedSole's entire BCBS series.

Update 4 -- 2026: The 21-Day Missing-Item Cancellation Clock

BCBS SC notifies providers of missing application items every 7 days with a maximum of 21 days -- if missing items are not received within the 21-day window, the application is canceled and the provider must submit a completely new application through MyPEP, losing all processing time accumulated on the canceled application.

An application canceled at day 22 due to missing items represents the entire credentialing timeline wasted -- the 60-to-90-day processing window restarts from zero on the new submission.

A practice that misses the 21-day clock extends its network effective date by the full credentialing timeline.

South Carolina practices managing the 21-day missing-item clock alongside MyPEP 2.0 navigation, Adobe Acrobat Sign e-signature, and 90-day CAA directory validation simultaneously are among the strongest cases for outsource provider enrollment -- the ROI resolves within the first billing cycle when all simultaneous BCBS SC enrollment obligations are factored into the internal management cost.

Update 5 -- 2026: 90-Day CAA Directory Validation Requirement

Under the Consolidated Appropriations Act (CAA), BCBS SC requires all enrolled providers to verify and update their demographic data at least every 90 days through M.D.

Checkup inside My Insurance Manager at provider.bcbssc.com -- and providers who haven't validated within 90 days can be suppressed from BCBS SC's provider directories until validation occurs, losing all directory referral visibility with no claim denial trigger that would alert the provider to the suppression.

Terminating or inactivating a location in M.D. Checkup stops claims adjudication for dates of service after the termination date -- BCBS SC explicitly states this in its [M.D.

Checkup User Guide -- Revised August 2025 -- 90-day CAA directory validation and location termination claims adjudication impact](https://provider.bcbssc.com/web/public/resources/fac2d7df-a906-4ac7-b0f4-fd83a4b141e1/MD%2BCheckup%2BGuide_08-07-2025.pdf). A provider who incorrectly terminates a location to update a demographic creates an immediate claims payment stop for that location.

Update 6 -- 2026: Virtual Care Not Automatic -- Separate MyPEP Application Required

BCBS SC does not automatically enroll providers in telehealth coverage -- providers who want to bill for telehealth or virtual care services with BCBS SC must complete a separate "Add Virtual Care" application type in MyPEP 2.0, which is distinct from the standard practitioner enrollment application and routes through a separate internal review pathway.

A provider who completes only the standard MyPEP practitioner enrollment and assumes telehealth is included will generate virtual care claim denials on every telehealth encounter.

Update 7 -- 2026: Recredentialing at 60 Days Can Trigger Termination and Full Re-Enrollment

BCBS SC recredentials network providers every three years -- and providers who miss the recredentialing date or who are within 60 days of their recredentialing due date may be terminated, requiring a completely new enrollment application through MyPEP rather than a recredentialing update, which means the full 60-to-90-day processing timeline applies to the new application.

Recredentialing notifications go directly to physicians -- facility administrators and group billing managers do not automatically receive recredentialing notifications for individual physicians in their practice. A practice that doesn't track the three-year recredentialing cycle independently may miss the notification and face full re-enrollment as a consequence.

Provider Types, Application Pathways, Three BCBS SC Checklists, and Why Behavioral Health Credentialing Routes Through CBA Not MyPEP

BlueCross BlueShield of South Carolina offers five distinct provider enrollment pathways -- individual practitioners using the Individual Checklist through MyPEP 2.0, group practices using the Group Practice Checklist through MyPEP 2.0, in-state out-of-network providers using the In-State Out-of-Network Checklist, mental health and substance abuse providers credentialing through CBA (Companion Benefit Alternatives) at cba.provrep@companiongroup.com rather than MyPEP, and ABA providers submitting the "Autism Provider Panel" application type in MyPEP -- each pathway requiring different documentation, different routing, and different timelines.

Selecting the wrong pathway wastes the entire South Carolina enrollment timeline.

Individual Practitioners -- Individual Checklist + MyPEP 2.0

Individual practitioners -- physicians, advanced practice providers, nurse practitioners, physician assistants, CRNAs, CNMs, CNSs, and hospital-based physicians -- use the Individual Checklist from southcarolinablues.com to confirm all required documentation before beginning the MyPEP 2.0 application.

BCBS SC explicitly categorizes mid-level providers -- including NPs, PAs, CRNAs, CNMs, and CNSs -- as a distinct checklist category with their own documentation requirements separate from MD/DO practitioners.

Our nurse practitioner credentialing guide covers the NP-specific BCBS SC documentation requirements including South Carolina Board of Nursing licensure and the specific MyPEP 2.0 application type for independent NP practitioners.

The Individual Checklist is the starting point -- every item must be gathered before the MyPEP session begins, because uploads are required at submission.

BCBS SC requires five years or 60 consecutive months of data for both medical license history and work history in every individual provider application.

The official BCBS SC Provider Enrollment PDF specifies this 60-month requirement explicitly -- a provider with less than five years of practice history in the United States must document the complete international practice history for the same 60-month window.

This is among the most rigorous history requirements in MedSole's BCBS series.

South Carolina physicians completing the 60-month license and work history requirement in MyPEP 2.0 should review our physician credentialing services guide -- covering the SC-specific physician documentation requirements including active South Carolina medical license from the SC Board of Medical Examiners, malpractice coverage meeting BCBS SC's minimum thresholds (often $1M/$3M for most provider types), DEA registration, and board certification for specialists.

Group Practices -- Group Practice Checklist + Individual Credentialing Distinction

BCBS SC's Provider Enrollment department handles only individual network credentialing -- group contracting for BlueChoice networks is negotiated separately by the Provider Contracting area and requires contacting Provider.Directory@bcbssc.com, not the standard MyPEP enrollment pathway -- and providers who submit a group enrollment through MyPEP expecting group contracting will receive individual credentialing only, without the group contract that authorizes billing under a group NPI.

Group practices use the Group Practice Checklist -- distinct from the Individual Checklist -- which includes additional documentation requirements for the group entity including IRS/TIN documentation (147C or CP575 letter), EFT documentation, and CMS letters where applicable per the January 2026 MyPEP 2.0 User Manual.

The difference between individual credentialing and group contracting isn't obvious until a claim denies because billing was attempted under a group NPI that was never contracted.

In-State Out-of-Network Providers -- Third Checklist Pathway

South Carolina providers who want to serve BCBS SC patients on an in-state out-of-network basis -- billing at out-of-network rates without full network credentialing -- use the In-State Out-of-Network Checklist, a third distinct pathway from the Individual and Group Practice checklists, and submit through a separate process from the standard MyPEP network participation application.

This pathway is for providers who treat BCBS SC patients without joining the network, not a shortcut to network participation.

Behavioral Health and Mental Health -- CBA, Not MyPEP

Mental health and substance abuse providers credentialing with BCBS SC do NOT submit through MyPEP -- CBA (Companion Benefit Alternatives) is an independent company that administers behavioral health benefits on behalf of BlueChoice HealthPlan, and all mental health and substance abuse credentialing routes through CBA at cba.provrep@companiongroup.com, which covers both the BlueChoice commercial network and the CBA-administered mental health network simultaneously.

Behavioral health providers who submit through MyPEP thinking it handles all BCBS SC credentialing will have their application returned -- because MyPEP routes behavioral health applications to a different review queue that refers providers to CBA rather than completing credentialing directly.

The time cost of this error equals the full 60-to-90-day credentialing window before the provider realizes they need to restart with CBA.

South Carolina behavioral health providers need CBA-specific credentialing capability -- not just standard BCBS SC MyPEP experience.

Our behavioral health credentialing services guide covers the complete CBA credentialing pathway for mental health and substance abuse providers in South Carolina, including the documentation requirements that differ from standard BlueCross individual practitioner credentialing.

Licensed therapists and licensed counselors in South Carolina credentialing through CBA should review our credentialing solutions for therapists guide -- covering the CBA-specific documentation requirements for South Carolina licensed professional counselors, licensed clinical social workers, and licensed marriage and family therapists.

The blue cross blue shield credentialing pathway for therapists in South Carolina routes through CBA, not MyPEP.

ABA Providers -- Autism Provider Panel Application Type in MyPEP

ABA providers credentialing with BCBS SC use the "Autism Provider Panel" application type in MyPEP 2.0 -- a distinct named application type separate from standard practitioner enrollment that routes through a specialized review pathway for autism services credentialing -- and South Carolina's mandatory ABA insurance coverage law makes BCBS SC network participation commercially significant for every ABA practice in the state.

Our ABA credentialing services guide covers the MyPEP 2.0 Autism Provider Panel application type and the South Carolina-specific ABA documentation requirements for BCBS SC commercial and Healthy Blue SC Medicaid network participation.

The credentialing with blue cross blue shield process for ABA providers begins with the correct application type selection -- selecting "Enroll a Practitioner" instead of "Autism Provider Panel" sends the application to an incorrect review queue.

See Provider Enrollment Checklists and Videos -- Individual, Group Practice, Other Checklists, and Educational Videos for MyPEP 2.0 for the complete three-checklist architecture and MyPEP 2.0 educational video resources.

The MyPEP 2.0 User Manual January 2026 -- application types including Autism Provider Panel, Add Virtual Care, and mid-level provider enrollment is the authoritative source for all application type routing.

BCBS SC Credentialing Inside MyPEP: CAQH ProView, Application Statuses, the 21-Day Missing-Item Clock, and the Staged Review Process

BCBS SC credentialing through MyPEP 2.0 follows a five-stage process -- preliminary review to confirm the application is clean, e-signing of agreements through Adobe Acrobat Sign using signature type "Type" not "Image," secondary review and credentialing including background checks and committee review, contracting establishing fee schedule terms, and finally loading the provider and issuing a welcome notification with network and affiliation effective dates -- and BCBS SC states explicitly that only clean applications progress through this staged review process.

The bcbs credentialing status at each stage maps to a named MyPEP status label.

CAQH ProView -- Required and Must Be Current at Submission

BCBS SC uses CAQH ProView as its preferred method for credentialing data -- providers must have a current CAQH ProView profile with active attestation within 120 days at the time BCBS SC's credentialing team reviews the application, and a lapsed CAQH attestation is one of the most frequently cited causes of BCBS SC application delays because the credentialing team cannot complete primary source verification from an expired profile.

Required CAQH ProView documentation for BCBS SC credentialing: active South Carolina medical license from the appropriate SC licensing board, five years or 60 consecutive months of license history and work history, malpractice insurance certificate meeting BCBS SC's coverage minimums (often $1M/$3M), DEA registration where applicable, board certification for specialists, and NPI number.

CAQH must be set to authorize BCBS SC as a participating health plan before submission.

Getting credentialed with bcbs South Carolina starts with CAQH completeness -- not MyPEP access. A provider who opens MyPEP before verifying CAQH completeness will discover the gap during the credentialing review, when the 21-day clock is already running.

See CAQH ProView -- BCBS SC's preferred credentialing data method, 120-day attestation requirement for registration and documentation requirements.

Our BCBS SC credentialing and enrollment service at $99 per payer includes CAQH ProView completeness verification as a standard workflow step -- preventing CAQH-related application delays from the first submission. The blue cross blue shield credentialing application process at BCBS SC moves forward only when CAQH is complete and attested.

MyPEP Application Statuses -- What Each Status Label Means

MyPEP 2.0 tracks application progress through four named status labels -- "In Progress" (application is being completed by the provider), "Submitted" (all required documentation uploaded and application submitted, pending review), "Awaiting Signature" (e-sign agreement routed through Adobe Acrobat Sign is waiting for signatures), and "Awaiting Provider Response" (additional information needed before processing can continue) -- and checking status requires navigating to Applications, then My In-Progress Applications in the MyPEP portal.

The bcbs credentialing status for any active application is visible in this navigation path.

The "Awaiting Provider Response" status is the critical alert -- it triggers the 21-day missing-item clock.

BCBS SC sends notifications every 7 days when an application is in "Awaiting Provider Response" status, with a 21-day maximum after which the application is canceled and a new submission is required.

See the MyPEP 2.0 User Manual -- January 2026 -- staged review process and application status labels for the complete status label definitions.

Primary Source Verification and Committee Review

After a clean application passes preliminary review, BCBS SC conducts primary source verification -- confirming credentials directly from licensing boards, medical schools, and certification bodies -- then forwards the file to the credentialing committee for review, and upon committee approval, the contracting step establishes the fee schedule terms before the provider is loaded to BCBS SC's systems and a welcome notification is issued with the network effective date.

The network effective date in BCBS SC's system is based on the contract signature date on the application -- not the date of committee approval and not the date the welcome notification is issued.

The effective date is not retroactive. BCBS SC explicitly states through the Healthy Blue SC Provider Administrative Manual that providers should not see patients until they receive their welcome email with network effective dates.

A provider who sees BCBS SC patients before receiving the welcome notification is seeing patients as an out-of-network provider -- generating out-of-network claims that may not be correctable to in-network status retroactively once the effective date is established.

The credentialing and contracting step that follows BCBS SC committee approval establishes fee schedule terms for every future BlueCross BlueShield of South Carolina claim and BlueChoice HealthPlan HMO claim -- MedSole RCM reviews the executed agreement before the provider's first BCBS SC billing date to confirm fee schedule terms are correctly configured for all active product lines.

How to Enroll With BCBS SC in 2026: The Complete MyPEP 2.0 Five-Step Process That Every Competitor Gets Wrong

To enroll with BCBS SC, open MyPEP (My Provider Enrollment Portal) 2.0 at bluecross-sc.my.site.com using Google Chrome, register an account if this is your first enrollment, select the correct application type for your provider category (Enroll a Practitioner, Enroll a Group, Behavioral Health, Autism Provider Panel, Add Virtual Care, or a maintenance action), download the checklist matching your provider type from southcarolinablues.com to confirm all required documentation, submit the Individual Provider Enrollment Application with initials and date on every page to Provider.Blue.Enroll@bcbssc.com or fax to 803-870-8919, complete the Adobe Acrobat Sign e-signature using type "Type" not "Image," respond to any missing-item notifications within 21 days to prevent application cancellation, and wait for the welcome notification email confirming your network effective date before seeing any BCBS SC patients.

Step 1: Access MyPEP 2.0 -- Google Chrome Required

Log into MyPEP 2.0 login at bluecross-sc.my.site.com -- Google Chrome recommended for optimal performance using Google Chrome -- BCBS SC specifically recommends Google Chrome for optimal performance. The MyPEP portal runs on Salesforce Community Cloud infrastructure, which is the reason for the my.site.com domain and the Google Chrome recommendation. Non-Chrome browsers may produce functionality issues.

New users must register an account in MyPEP before submitting any application.

Account registration requires provider NPI, Tax ID, and a valid email address that will receive all subsequent MyPEP notifications including missing-item alerts and the Adobe Acrobat Sign e-signature email.

The MyPEP login is the gateway to all subsequent enrollment steps.

Internet Explorer and non-Chrome browsers may produce functionality issues in MyPEP -- Salesforce Community Cloud, the technology platform powering MyPEP at the my.site.com domain, performs optimally on Chrome.

A non-Chrome browser submission may appear to succeed while producing a corrupted application file on BCBS SC's end. See the BCBS SC Join Our Networks -- MyPEP 2.0 official enrollment pathway for the official enrollment pathway confirmation.

Step 2: Select the Correct Application Type -- This Controls All Downstream Routing

The application type selected in MyPEP 2.0 controls which internal review pathway the application routes through -- selecting the wrong application type (for example, selecting "Enroll a Practitioner" for an ABA provider who should select "Autism Provider Panel") sends the application to an incorrect review queue, creating delays while BCBS SC's enrollment team identifies the routing error and instructs the provider to resubmit with the correct application type. This is the most consequential single decision in the entire South Carolina enrollment form submission.

Named MyPEP application types per the January 2026 User Manual: Enroll a Practitioner, Enroll a Group, Add Virtual Care, Behavioral Health, Autism Provider Panel, Change of Address, Add Satellite Location, NPI Provider Notification, Request to Add a Practitioner, Remove a Practitioner.

Behavioral health providers use CBA at cba.provrep@companiongroup.com -- not the Behavioral Health application type in MyPEP.

Step 3: Download the Correct Checklist and Gather All Required Documentation

Download the checklist that matches your provider type from southcarolinablues.com before preparing any documentation -- Individual Checklist for solo practitioners, Group Practice Checklist for group and multi-location practices, In-State Out-of-Network Checklist for out-of-network status applications. Each checklist item hyperlinks to the required form or example directly from the BCBS SC website. The bcbs sc provider enrollment form pdf for physicians is the Individual Provider Enrollment Application, not the checklist itself.

Required documentation for most individual practitioner applications: active South Carolina medical license, 60-month license and work history, malpractice insurance certificate (often $1M/$3M minimum), DEA registration where applicable, board certification for applicable specialties, NPI number, and CAQH ProView with active attestation within 120 days.

CAQH must be current before submitting -- a lapsed CAQH profile stops the credentialing review.

Step 4: Submit the Application -- Initials and Date on Every Page

The Individual Provider Enrollment Application requires provider initials and date on every page before submission -- BCBS SC's application PDF explicitly states this requirement, and applications submitted without initials and dates on all pages are returned for correction, adding to the 21-day missing-item window and potentially triggering the application cancellation clock if the correction isn't returned in time.

Submit completed applications to Provider.Blue.Enroll@bcbssc.com or fax to 803-870-8919.

Call 800-868-2510 before submitting -- when the IVR prompts you, say "Provider Enrollment" -- to confirm panel availability for your specialty before investing documentation preparation time in a closed network.

See the Individual Provider Enrollment Application -- initials and date required on every page, submit to Provider.Blue.Enroll@bcbssc.com or fax 803-870-8919 for the current application PDF.

MedSole RCM confirms panel availability before any documentation begins, prepares complete CAQH ProView data to the 120-day attestation standard, selects the correct MyPEP application type for every provider category, and ensures initials and dates appear on every page of the application -- all for full-service provider enrollment at $99 per payer with a 99 percent first-time approval rate.

Becoming a bcbs provider in South Carolina doesn't require guessing the correct pathway -- MedSole confirms it before documentation begins.

Step 5: Complete the Adobe Acrobat Sign E-Signature and Monitor Status

After submitting the application in MyPEP, the e-sign agreement routes through Adobe Acrobat Sign to the email addresses entered in MyPEP's practitioner, credentialing contact, and fiduciary contact fields -- providers must ensure @bcbssc.com emails are not treated as spam, sign using type "Type" not "Image" in Adobe Acrobat Sign to include the required date and time stamp, and monitor MyPEP status under Applications, then My In-Progress Applications for any transition to "Awaiting Provider Response" that triggers the 21-day missing-item clock.

Once the credentialing committee approves and the contracting step is complete, a welcome notification email confirms the network effective date -- the date from which BCBS SC patients can be billed as in-network.

Do not see BCBS SC patients before receiving this welcome notification. The contract signature date on the application determines the effective date -- not the committee approval date and not the welcome notification date.

MyPEP 2.0 vs. My Insurance Manager: Two Separate Systems With Two Separate Functions -- and the M.D. Checkup 90-Day CAA Compliance Requirement

BCBS SC operates two distinct provider portal systems with completely different functions -- MyPEP (My Provider Enrollment Portal) 2.0 at bluecross-sc.my.site.com for enrollment applications, maintenance requests, status tracking, and demographic updates during the enrollment process, and My Insurance Manager at provider.bcbssc.com for daily operational functions including eligibility verification, claims submission, claims status, prior authorization, remittance viewing through My Remit Manager, and the 90-day CAA directory validation through M.D.

Checkup -- and confusing which system handles which function is one of the most common operational errors for newly enrolled South Carolina providers. MyPEP and My Insurance Manager are two different URLs with two different purposes.

MyPEP 2.0 -- Enrollment, Maintenance, and Demographic Updates

MyPEP 2.0 at bluecross-sc.my.site.com handles: new practitioner enrollment, new group enrollment, maintenance requests (adding a network, removing a location, adding a satellite location, changing address, adding or removing practitioners from a group), and virtual care enrollment.

MyPEP's educational video resources are available on the Provider Enrollment Checklists and Videos page at southcarolinablues.com -- the only official BCBS SC training video resource for the current MyPEP 2.0 portal.

Provider Portal 2.0 is the named system upgrade that BCBS SC references in its 2022 enrollment process announcement -- this is MyPEP 2.0, the Salesforce Community Cloud-based portal.

Providers searching for "provider portal 2.0" for BCBS SC are searching for MyPEP 2.0 at bluecross-sc.my.site.com. The bcbs south carolina provider portal and provider portal 2.0 both refer to MyPEP 2.0 at this domain.

My Insurance Manager -- Daily Operations at provider.bcbssc.com

My Insurance Manager at provider.bcbssc.com is BCBS SC's operational provider portal for all daily functions after enrollment is complete -- eligibility and benefits verification, claims submission, claim status inquiry, prior authorization requests, access to My Remit Manager for viewing and printing electronic remittance advices from 835 files, and M.D.

Checkup for the 90-day CAA directory validation requirement. The myinsurancemanager sc portal is separate from MyPEP and handles every function that a newly enrolled provider uses daily.

Real-time verification of benefits through My Insurance Manager at provider.bcbssc.com for every BCBS SC patient -- commercial BlueCross, BlueChoice HMO, Healthy Blue SC Medicaid, BlueCross Medicare Advantage, and FEP -- before each encounter prevents eligibility-related denials and confirms which of the four BCBS SC product lines the patient carries before any service is rendered.

The my insurance manager bcbs sc portal at provider.bcbssc.com is the daily operational home for every enrolled South Carolina provider.

See the BCBS SC My Insurance Manager at provider.bcbssc.com -- operational provider portal for current portal access and operational function documentation. The my insurance manager south carolina blues system hosts all claim and eligibility functions after credentialing approval.

M.D. Checkup -- The 90-Day CAA Directory Validation Inside My Insurance Manager

M.D.

Checkup is a feature inside My Insurance Manager at provider.bcbssc.com that providers use to fulfill the 90-day CAA directory validation requirement -- effective January 1, 2022 under the Consolidated Appropriations Act, BCBS SC requires all enrolled providers to verify and update demographic data at least every 90 days or be suppressed from provider directories without any claim denial trigger to alert the provider that suppression has occurred.

The suppression consequence is revenue-silent -- a provider removed from BCBS SC's directory due to missed 90-day validation loses referral visibility from BCBS SC members searching for in-network providers, but no claim denial fires.

The revenue impact begins the moment the directory listing disappears, not when a claim is submitted. The 90-day CAA directory validation through M.D.

Checkup is the most operationally dangerous compliance obligation in BCBS SC's enrollment architecture precisely because it fails silently. See [M.D.

Checkup User Guide -- Revised August 2025 -- 90-day CAA directory validation and location termination claims adjudication impact](https://provider.bcbssc.com/web/public/resources/fac2d7df-a906-4ac7-b0f4-fd83a4b141e1/MD%2BCheckup%2BGuide_08-07-2025.pdf) for the complete user guide.

Terminating or inactivating a location in M.D. Checkup stops claims adjudication for all dates of service after the termination date -- per BCBS SC's M.D. Checkup User Guide revised August 2025.

A provider who incorrectly terminates a location to update a demographic creates an immediate claims payment stop that requires BCBS SC intervention to restore. This is a named warning in BCBS SC's own official user guide, not speculation.

MedSole RCM handles prior authorization routing through My Insurance Manager for standard BlueCross BlueShield of South Carolina and BlueChoice HealthPlan services -- including prior authorization requirements for BlueCross Total PPO and BlueCross Blue Basic PPO Medicare Advantage products where members don't need referrals but specific services require plan authorization.

The myinsurancemanager portal at provider.bcbssc.com and the www.myinsurancemanager portal are the same operational system.

Three Separate South Carolina BCBS Provider Tracks: Healthy Blue SC Medicaid, Select Health State Employees, and FEP Federal Employee Program

South Carolina providers who want to serve the full range of BCBS SC-covered patients must complete three separate enrollment tracks beyond commercial BlueCross BlueShield of South Carolina credentialing -- Healthy Blue SC Medicaid through MyPEP with a validated SCDHHS Medicaid ID assigned to the practitioner NPI as a mandatory prerequisite, Select Health of South Carolina for state government employees through a separate enrollment track, and the Federal Employee Program (FEP) administered by BCBS SC for South Carolina's federal employees, military retirees, and their dependents.

The sc medicaid provider enrollment and south carolina medicaid provider enrollment pathways both run through Healthy Blue SC for BCBS SC patients.

Healthy Blue SC -- The BCBS SC Medicaid MCO Track

Healthy Blue SC is BlueCross BlueShield of South Carolina's Medicaid MCO product participating in South Carolina Healthy Connections -- the South Carolina Department of Health and Human Services (SCDHHS) managed care program -- and Healthy Blue SC enrollment through MyPEP requires a SCDHHS Medicaid ID that is validated and active with SCDHHS AND assigned to the practitioner or group NPI (not the Tax Identification Number) before the MyPEP application is submitted, because BCBS SC won't consider any Healthy Blue SC application where the Medicaid ID cannot be validated during review.

SCDHHS partners with five Medicaid MCOs for South Carolina Healthy Connections managed care. Healthy Blue SC is one of those five.

Providers who want to serve Healthy Blue SC Medicaid patients must select "Healthy Blue" in the Network Selection section of the MyPEP application -- and this selection must be made on a separate application from commercial BlueCross enrollment, not on the same application.

Healthy Blue SC's effective dates are the date of credentialing committee approval and are not retroactive.

Providers must not see Healthy Blue SC Medicaid patients until they receive their welcome email confirming network effective dates -- a provider who sees patients before the welcome email is billing as out-of-network on every Medicaid claim.

See Healthy Blue SC Provider Administrative Office Manual -- Medicaid ID NPI assignment required, effective dates not retroactive, 90-day directory validation for the official confirmation.

The federal regulatory framework under 42 CFR Part 455 that governs South Carolina Healthy Connections -- including the SCDHHS enrollment prerequisite and the state-by-state MCO variation that makes South Carolina's Medicaid ID NPI assignment requirement distinct from every other state's Medicaid enrollment process -- is covered in our national Medicaid provider enrollment hub.

South Carolina Medicaid practices enrolling with multiple Healthy Connections MCOs alongside Healthy Blue SC should review our Molina credentialing and Aetna provider enrollment guides -- Molina Healthcare of South Carolina and Aetna Better Health of South Carolina are separate Healthy Connections MCOs that each require independent credentialing from Healthy Blue SC's MyPEP enrollment.

Navigating SCDHHS enrollment, Healthy Blue SC Medicaid ID NPI assignment, MyPEP network selection, and Healthy Connections MCO multi-credentialing simultaneously is why South Carolina Medicaid practices choose Medicaid credentialing experts over internal credentialing management.

See SCDHHS MCO Providers -- BlueChoice Healthy Blue among South Carolina's five Healthy Connections MCOs for the official five-MCO confirmation from SCDHHS.

Healthy Blue SC BlueBlast -- The Official Provider Newsletter

BlueBlast is Healthy Blue SC's monthly provider newsletter -- delivering articles on programs, policies, upcoming initiatives, and operational updates directly to enrolled providers at healthybluesc.com/providers/provider-news -- and every Healthy Blue SC enrolled provider should subscribe to BlueBlast as the primary channel for 2026 Medicaid policy changes including HCPCS codes January 1, 2026 updates and the January 22, 2026 DME Continuity of Services requirement.

The healthy blue sc provider phone number for Medicaid-specific inquiries is 855-811-2218.

Select Health of South Carolina -- State Employees Track

Select Health of South Carolina administers the Standard Plan for South Carolina state government employees -- one of two State Health Plan options -- and BlueCross BlueShield of South Carolina serves as the third-party administrator for the State Health Plan, meaning enrolled BCBS SC commercial providers are positioned to serve South Carolina's state government employees including teachers, state agency workers, and their families through the Select Health of South Carolina plan.

The select health of south carolina provider portal and the south carolina healthy connections provider phone number function operate separately from the standard BCBS SC commercial enrollment pathway.

Select Health provider enrollment routes through a separate pathway from standard commercial BlueCross credentialing.

Providers with questions about Select Health of South Carolina participation should contact BCBS SC's provider enrollment team at 800-868-2510, saying "Provider Enrollment" when the IVR prompts, to confirm the specific Select Health enrollment pathway for their provider type.

The select health of south carolina provider phone number for state employee enrollment inquiries runs through the same 800-868-2510 line with the "Provider Enrollment" IVR routing.

FEP -- Federal Employee Program Provider Enrollment

BCBS SC administers the Federal Employee Program (FEP) in South Carolina for federal government employees, military retirees, and their dependents -- creating a separate provider credentialing track from commercial BCBS SC products -- and South Carolina's military concentration (Fort Jackson, Joint Base Charleston, MCAS Beaufort, Parris Island, Shaw AFB) makes FEP one of the most commercially significant supplemental enrollment tracks for South Carolina providers who also see TRICARE active-duty military patients.

Our TRICARE credentialing guide covers the complete TRICARE enrollment pathway for South Carolina providers -- TRICARE for active-duty military members and BCBS SC FEP for military retirees and federal employees are two separate enrollment systems that together cover a substantial portion of South Carolina's insured population near military installations.

Post-Enrollment Setup: EFT via Provider.EFT@bcbssc.com, ERA via EDI.Services@bcbssc.com, My Remit Manager, BlueCard Routing, and Avalon Lab Benefits After Credentialing Approval

After receiving the BCBS SC welcome notification with network effective date, four post-enrollment steps determine when the first payment arrives -- EFT enrollment by submitting the Electronic Funds Transfer Application to Provider.EFT@bcbssc.com (with a 2-to-4-week test period before the effective EFT date is confirmed by email), ERA enrollment by submitting the EDIG ERA enrollment form to EDI.Services@bcbssc.com (takes up to one week to activate), activating My Remit Manager inside My Insurance Manager for 835 electronic remittance advice viewing, and understanding that Avalon manages lab benefit authorization independently from standard BCBS SC claims processing.

EFT -- Electronic Funds Transfer via Provider.EFT@bcbssc.com

BCBS SC EFT enrollment requires completing the Electronic Funds Transfer Application form and submitting it to Provider.EFT@bcbssc.com -- after a new bank account is loaded, a test period of two to four weeks begins depending on how frequently claims are filed, and providers receive an email from BCBS SC confirming the EFT effective date once the test period completes successfully.

Unlike Florida Blue which routes EFT through Availity Essentials' Enrollments Center, and unlike Anthem BCBS Virginia which uses EnrollSafe for EFT, BCBS SC routes EFT enrollment through a dedicated email address -- Provider.EFT@bcbssc.com -- with no Availity portal step involved.

Providers who attempt to set up EFT through My Insurance Manager without submitting the EFT Application form will find no EFT enrollment function inside the operational portal.

See BCBS SC EFT and ERA enrollment -- Provider.EFT@bcbssc.com, 2-4 week test period, EDI.Services@bcbssc.com, My Remit Manager for the official EFT and ERA enrollment documentation.

When EFT isn't yet configured and BCBS SC claims are processing but payments aren't routing electronically, active AR follow up is the recovery pathway -- MedSole RCM initiates EFT enrollment through Provider.EFT@bcbssc.com on the day of credentialing approval to eliminate any gap between network effective date and first electronic payment.

ERA -- Electronic Remittance Advice via EDI.Services@bcbssc.com

BCBS SC ERA (835 remittance) enrollment requires submitting the appropriate EDIG ERA enrollment form to EDI.Services@bcbssc.com -- with two separate form versions depending on whether the practice submits directly or uses a clearinghouse -- and ERA enrollment takes up to one week to activate, after which providers and billing services access 835 files through My Remit Manager inside My Insurance Manager at provider.bcbssc.com.

My Remit Manager is BCBS SC's free 835 remittance viewing tool for enrolled providers -- it accepts 835 files and allows viewing and printing by file, by check number, and by patient.

Providers who don't enroll in ERA through EDI.Services@bcbssc.com can't access My Remit Manager's claims reconciliation functions regardless of My Insurance Manager portal access. For ERA support, providers can also email EDI.Services@bcbssc.com or call Provider Education at 803-264-4730.

BlueCard -- Out-of-State BCBS Members at South Carolina Practices

BlueCard is the BCBS program through which enrolled BCBS SC providers serve out-of-state BCBS members who receive care in South Carolina -- BCBS SC handles all the paperwork for BlueCard claims, members don't complete claim forms, and the BlueCard member eligibility line is 800-676-BLUE (2583) for providers to verify benefits for members whose coverage originates from another BCBS plan outside South Carolina.

This is the bcbs federal provider phone number for eligibility verification for out-of-state members -- distinct from 800-868-2510 which is the Provider Services line for enrollment inquiries.

Avalon Lab Benefits -- Post-Enrollment Operational Awareness

Avalon manages lab benefit authorization and reimbursement on behalf of BCBS SC independently from the standard claims pathway -- providers who perform laboratory services or order lab work for BCBS SC commercial members interact with Avalon's separate lab benefits system, and understanding Avalon's independent role prevents lab-related claims from being submitted through the standard BCBS SC claims pathway incorrectly.

Avalon is the named operational lab partner that no other independent BCBS SC source has ever documented -- and its independence from MyPEP means the enrollment process gives no indication that Avalon will be involved in post-enrollment operations.

BCBS SC Provider Compliance Calendar: Five Independent Ongoing Obligations Every Enrolled South Carolina Provider Manages Simultaneously in 2026

BCBS SC network participation in 2026 requires managing five independent compliance deadlines simultaneously -- a 90-day demographic validation cycle through M.D.

Checkup inside My Insurance Manager under the federal CAA requirement (where missed validation causes directory suppression without any claim denial trigger), a 120-day CAQH ProView re-attestation cycle, a 3-year recredentialing cycle (where being within 60 days of the due date can trigger termination requiring full new enrollment), a 7-day missing-item notification response window within a 21-day maximum before application cancellation, and an ongoing network effective date compliance requirement where no patients are seen before the welcome notification confirms active status.

The bcbs credentialing status across all five obligations must be tracked independently -- none of them triggers an alert through another.

Every 90 Days -- M.D. Checkup Directory Validation in My Insurance Manager

Every 90 days, enrolled BCBS SC providers must log into My Insurance Manager at provider.bcbssc.com, navigate to M.D.

Checkup, and verify and update their demographic data to satisfy the federal CAA requirement effective January 1, 2022 -- providers who exceed 90 days without validation are suppressed from BCBS SC's provider directories with no claim denial firing to alert them, and the only way to confirm suppression has occurred is to search the BCBS SC public provider directory and find the listing absent.

Directory suppression is commercially silent -- patients searching for in-network providers can't find the suppressed provider, new patient volume drops, but no billing error appears in the practice management system. The revenue impact accumulates invisibly until the next 90-day validation restores the directory listing.

When validating in M.D. Checkup, never terminate or inactivate a location without intending to permanently stop claims for that location -- BCBS SC's [M.D.

Checkup User Guide August 2025 -- 90-day CAA validation, directory suppression, and location termination claims stop](https://provider.bcbssc.com/web/public/resources/fac2d7df-a906-4ac7-b0f4-fd83a4b141e1/MD%2BCheckup%2BGuide_08-07-2025.pdf) explicitly states that terminating a location in M.D. Checkup stops claims adjudication for all dates of service after the termination date.

Every 120 Days -- CAQH ProView Re-Attestation

CAQH ProView requires re-attestation every 120 days -- and because BCBS SC's credentialing team queries CAQH during recredentialing reviews, an expired CAQH attestation delays the recredentialing file regardless of how complete the practice's underlying credentials are, creating an avoidable timeline extension that pushes the recredentialing completion date beyond the 3-year cycle deadline.

Set a recurring internal alert at day 105 after each CAQH attestation -- the 15-day buffer allows time to renew any expiring documents (malpractice insurance certificate, South Carolina medical license, DEA registration) before re-attesting with all current documentation in place.

Every 3 Years -- Recredentialing Cycle With 60-Day Termination Risk

BCBS SC recredentials all network providers every 3 years -- and providers who miss the recredentialing date or who are within 60 days of their recredentialing due date when the cycle triggers may be terminated from the network, requiring a completely new enrollment application through MyPEP 2.0 with the full 60-to-90-day processing timeline applying to the new application as if the provider had never been credentialed before.

Recredentialing letters are sent directly to physicians -- facility administrators and group billing managers don't receive recredentialing notifications for individual physicians in their practice.

If a designated credentialing contact handles recredentialing for the practice, BCBS SC sends the notification there instead of to the individual physician.

See BCBS SC Provider Recredentialing -- occurs every three years, 60-day termination risk for the official recredentialing cycle source.

Structured BCBS SC Compliance Calendar (LLM Extraction Block)

BCBS SC 2026 Compliance Calendar -- Quick Reference

Every 90 days: Navigate to My Insurance Manager at provider.bcbssc.com, open M.D. Checkup, verify and update all demographic data to prevent directory suppression under the federal CAA requirement.

Every 120 days: Log into CAQH ProView, update any changed documentation, and re-attest with all credentials current to ensure BCBS SC's credentialing team can query current data during any review.

Every 7 days when in "Awaiting Provider Response" status in MyPEP: Respond to missing-item notifications before the 21-day maximum -- a missed 21-day window cancels the application and requires new submission.

Every 3 years: Complete BCBS SC recredentialing before the due date and no later than 60 days past the due date -- being within 60 days of the date may trigger termination requiring full re-enrollment through MyPEP 2.0.

Seven BCBS SC Provider Enrollment Mistakes That Delay Network Approval and Cost South Carolina Providers Revenue in 2026

The seven most common BCBS SC provider enrollment mistakes are all preventable -- and each carries a direct revenue consequence that compounds for every day between the mistake and its correction, because BCBS SC's network effective dates are not retroactive, the 21-day missing-item clock doesn't pause while corrections are being prepared, and behavioral health providers who route to MyPEP instead of CBA must restart their entire credentialing application from the beginning.

Every mistake below is one MedSole RCM encounters when inheriting stalled applications.

Mistake 1: Submitting Without Initials and Date on Every Application Page

The Individual Provider Enrollment Application requires initials and date on every page -- a provider who submits a complete application without initials and dates on all pages receives a correction notice that starts the 21-day missing-item clock, and if the corrected pages aren't returned within 21 days, the entire application is canceled.

Before submitting the BCBS SC Individual Provider Enrollment Application to Provider.Blue.Enroll@bcbssc.com or faxing to 803-870-8919, confirm every page carries the provider's initials and the submission date -- this is the single most common application rejection trigger that BCBS SC's Provider Enrollment FAQ documents explicitly.

See BCBS SC Provider Enrollment FAQs -- initials and date requirement, application type routing, behavioral health CBA pathway for the official FAQ confirmation.

Mistake 2: Routing Behavioral Health Credentialing Through MyPEP Instead of CBA

A mental health or substance abuse provider who submits through MyPEP 2.0 thinking it handles all BCBS SC credentialing has their application returned -- because CBA (Companion Benefit Alternatives) at cba.provrep@companiongroup.com is the correct pathway for all behavioral health credentialing, and the MyPEP submission adds no processing progress toward network participation.

South Carolina mental health and substance abuse providers must contact CBA directly at cba.provrep@companiongroup.com before beginning any BCBS SC credentialing documentation -- CBA administers all behavioral health credentialing on behalf of BlueChoice HealthPlan, and no MyPEP submission replaces or initiates this process.

This is the most SC-specific mistake in MedSole's entire BCBS series -- no other BCBS state routes behavioral health through a named independent company.

Mistake 3: Selecting the Wrong MyPEP Application Type

Selecting "Enroll a Practitioner" for a provider who should select "Autism Provider Panel" or "Add Virtual Care" routes the application to an incorrect internal review queue -- BCBS SC identifies the routing error and instructs the provider to resubmit with the correct application type, losing the days accumulated on the incorrectly routed application.

The first decision in every MyPEP 2.0 submission is the application type -- confirm the correct type (Enroll a Practitioner, Enroll a Group, Behavioral Health, Autism Provider Panel, Add Virtual Care, or a maintenance action) before uploading any documentation, because incorrect application type selection wastes the entire documentation preparation investment.

The blue cross blue shield credentialing application process starts with this single selection.

Mistake 4: Using Image Signature Instead of Type Signature in Adobe Acrobat Sign

"Image" signatures in Adobe Acrobat Sign lack the required date and time stamp -- BCBS SC returns Image-signed agreements for correction, the e-sign process restarts, and the application sits in "Awaiting Signature" status while the corrected signature is re-routed.

Using "Type" in Adobe Acrobat Sign is not a preference -- it's a named technical requirement in the BCBS SC enrollment process.

Mistake 5: Missing the 21-Day Missing-Item Clock

A provider who receives a BCBS SC missing-item notification and doesn't respond within 21 days has their entire application canceled -- all documentation preparation, CAQH ProView completeness work, and processing time accumulated is lost, and a new application through MyPEP 2.0 must be submitted from scratch with the full 60-to-90-day timeline restarting.

Mistake 6: Submitting Healthy Blue SC Application Without a Validated SCDHHS Medicaid ID Assigned to the NPI

BCBS SC won't consider any Healthy Blue SC application where the Medicaid ID cannot be validated during review -- a provider who submits a Healthy Blue SC application through MyPEP without a SCDHHS-registered Medicaid ID assigned to the practitioner NPI (not the Tax ID) has the application rejected and must resubmit after obtaining the Medicaid ID.

The NPI assignment requirement -- not the TIN assignment -- is the specific technical distinction that makes this mistake the most common Healthy Blue SC enrollment failure.

Mistake 7: Seeing Patients Before the Welcome Notification Arrives

The BCBS SC network effective date is determined by the contract signature date -- not the credentialing committee approval date and not the date the provider believes they're credentialed.

Seeing BCBS SC patients before receiving the welcome notification email means billing as an out-of-network provider with no retroactive correction pathway once the effective date is established.

MedSole RCM prevents all seven mistakes by confirming the correct MyPEP application type before any documentation begins, routing behavioral health providers to CBA before the first document is prepared, initiating all applications with complete initials and dates on every page, monitoring Adobe Acrobat Sign for correct signature type, tracking the 21-day missing-item clock actively, coordinating SCDHHS Medicaid ID NPI assignment before any Healthy Blue SC application is submitted, and confirming the welcome notification before advising the practice to begin seeing BCBS SC patients -- all for $99 per payer with a 99 percent first-time approval rate.

When enrollment mistakes have already reached the claims stage -- out-of-network billing before welcome notification, Healthy Blue SC Medicaid claims without active credentialing, or systematic HCPCS code denials since January 1, 2026 -- active denials management is the only recovery pathway for accumulated out-of-network write-offs and HCPCS code denials.

Is BCBS SC the Same as BCBS Illinois, BCBS Virginia, or Florida Blue? The Five-Family BCBS Architecture -- Complete

BlueCross BlueShield of South Carolina shares no enrollment system, provider portal, credentialing vendor, behavioral health administrator, or operational infrastructure with any other BCBS plan in the United States -- because the Blue Cross Blue Shield Association licenses its name to five architecturally distinct parent company structures: Health Care Service Corporation (HCSC), Elevance Health (Anthem), GuideWell, and independent single-state licensees in two sub-types, with BlueCross BlueShield of South Carolina representing the fifth and final architecture as an independent mutual insurance company that also administers the Federal Employee Program.

The question "what is bcbs called in south carolina" is answered by one independent mutual company -- BlueCross BlueShield of South Carolina -- with four distinct product entities.

Architecture 1 -- HCSC: BCBS IL, NM, TX, OK, MT

Health Care Service Corporation operates BCBS plans in Illinois, New Mexico, Texas, Oklahoma, and Montana. HCSC plans use a Provider Onboarding Form with Verisys credentialing verification -- not MyPEP, not Salesforce Community Cloud, not CBA for behavioral health.

Our BCBS IL provider enrollment guide covers the HCSC architecture -- Verisys verification is HCSC's equivalent of BCBS SC's CBA behavioral health credentialing in terms of being a named third-party operational partner that providers encounter during credentialing but that no independent guide explains.

Our BCBS NM provider enrollment guide covers the BCBSNM HCSC pathway -- no MyPEP, no CBA, no independent mutual structure.

Architecture 2 -- Elevance Health/Anthem: BCBS VA and 13 Other States

Anthem Blue Cross and Blue Shield of Virginia is operated by Elevance Health -- routes behavioral health through Carelon Behavioral Health (not CBA), uses EnrollSafe for EFT (not Provider.EFT@bcbssc.com), and uses Availity Essentials as the provider portal (not MyPEP at bluecross-sc.my.site.com).

Our BCBS Virginia provider enrollment guide covers the Elevance Health architecture -- Carelon for behavioral health vs. CBA for South Carolina is the most architecturally significant behavioral health credentialing contrast in MedSole's BCBS series.

The contrast between CBA and Carelon illustrates why BCBS behavioral health credentialing requires payer-specific expertise rather than generic credentialing knowledge.

Architecture 3 -- GuideWell: Florida Blue

Florida Blue is operated by GuideWell Mutual Holding Corporation -- uses Medversant for credentialing verification (not CAQH-only like BCBS SC), requires dual-entity enrollment for both BCBSFL Inc. and Health Options Inc. HMO, and uses Availity Essentials at pssportal.bcbsfl.com rather than MyPEP.

Our BCBS FL provider enrollment guide covers the GuideWell architecture -- Medversant verification vs. BCBS SC's CAQH-primary approach and Lucet behavioral health vs. CBA represent the two most significant operational distinctions between Architecture 3 and Architecture 5.

Architecture 4 -- Independent Single-State Licensees: BCBS NC, BCBS MI, Horizon NJ

Blue Cross Blue Shield of North Carolina, Blue Cross Blue Shield of Michigan, and Horizon Blue Cross Blue Shield of New Jersey are all independent BCBS licensees -- the same structural family as BlueCross BlueShield of South Carolina -- but each with completely separate enrollment systems, provider portals, and credentialing processes.

Our BCBS NC provider enrollment guide covers the North Carolina independent licensee pathway -- BCBS NC directly borders South Carolina, making it the most geographically relevant non-SC BCBS plan for Southeast providers with practices in both states.

Our BCBS Michigan provider enrollment guide covers BCBSM's independent enrollment architecture -- no MyPEP, no CBA, no shared infrastructure with BCBS SC.

Our BCBS NJ provider enrollment guide covers Horizon's independent enrollment pathway -- entirely separate from BlueCross BlueShield of South Carolina.

Architecture 5 -- BlueCross BlueShield of South Carolina (Independent Mutual + FEP Administrator)

BlueCross BlueShield of South Carolina is an independent mutual insurance company established 1946 -- the fifth and most operationally distinct BCBS architecture. MyPEP 2.0 at bluecross-sc.my.site.com, CBA for behavioral health, Provider.EFT@bcbssc.com for EFT, M.D.

Checkup for 90-day CAA validation, and FEP administration are all unique to this architecture -- appearing in no other BCBS plan's enrollment infrastructure.

South Carolina providers who also see United Healthcare, Aetna, or Cigna patients manage three additional independent enrollment systems. Our United Healthcare credentialing, Aetna provider enrollment, and Cigna provider enrollment guides cover the SC-specific enrollment pathways for each.

South Carolina healthcare providers searching for the most affordable provider enrollment service for BCBS SC commercial, BlueChoice HealthPlan HMO, Healthy Blue SC Medicaid, BlueCross Medicare Advantage, and FEP enrollment will find that MedSole RCM manages all five tracks at $99 per payer -- with MyPEP 2.0 navigation, CBA behavioral health routing, 21-day missing-item clock management, and SCDHHS Medicaid ID NPI assignment coordination as standard workflow steps -- with 900 or more active payer relationships, all-50-state coverage, and a 99 percent first-time approval rate.

BCBS SC Provider Contacts, Phone Numbers, Emails, Fax Numbers, and Official Resources for 2026

The contacts below are the official BlueCross BlueShield of South Carolina provider enrollment, credentialing, EFT, ERA, and directory management contacts for 2026 -- sourced from southcarolinablues.com/providers, provider.bcbssc.com, the January 2026 MyPEP 2.0 User Manual, the August 2025 M.D.

Checkup User Guide, and the official BCBS SC Join Our Networks page. Have your NPI and Tax ID ready before calling any provider line.

See BCBS SC official provider enrollment contacts -- 800-868-2510, 803-264-0181, 855-811-2218 for the official contacts page.

The bcbs sc provider phone number, the bcbs sc provider enrollment phone number, and the blue cross of south carolina provider phone number all route through 800-868-2510 as the primary line.

800-868-2510 is the correct escalation contact for provider enrollment inquiries -- say "Provider Enrollment" when the IVR prompts to reach the correct department. 803-264-0181 and 855-811-2218 are the secondary and Healthy Blue SC-specific lines respectively.

For behavioral health credentialing, contact CBA at cba.provrep@companiongroup.com directly -- do not call 800-868-2510 for behavioral health credentialing questions as that line routes to commercial enrollment, not CBA.

See BCBS SC Join Our Networks -- call 800-868-2510 and say Provider Enrollment when prompted for the IVR routing instruction source.

PAA Answer Block: Four BCBS SC Provider Enrollment Questions Answered Directly

The four most frequently asked questions about BCBS SC provider enrollment -- each answered with the operational detail that current SERP sources don't provide.

What Is the Phone Number for BCBS SC Provider Credentialing?

The phone number for BCBS SC provider credentialing is 800-868-2510 -- when the IVR system prompts you, say "Provider Enrollment" to reach the provider enrollment team who can assist with MyPEP 2.0 access, application status, and credentialing questions.

For application submission specifically, email Provider.Blue.Enroll@bcbssc.com or fax to 803-870-8919. For Healthy Blue SC Medicaid provider inquiries, call 855-811-2218. For secondary provider contact needs, 803-264-0181 is BCBS SC's alternate provider line.

For behavioral health credentialing through CBA, contact cba.provrep@companiongroup.com directly -- 800-868-2510 does not route to CBA.

Using 800-868-2510 without saying "Provider Enrollment" at the IVR routes to a general menu.

For credentialing status specifically, email provider.cert@bcbssc.com rather than calling -- the dedicated credentialing status email produces faster responses than the phone line for status-only inquiries.

The bcbs sc provider enrollment number for all enrollment documentation questions is 800-868-2510 with the "Provider Enrollment" IVR script.

How Do I Contact BCBS of SC?

To contact BlueCross BlueShield of South Carolina as a provider, call 800-868-2510 and say "Provider Enrollment" when the IVR prompts -- this routes to the provider enrollment team for MyPEP 2.0 support, application status, and credentialing questions.

For application submission, email Provider.Blue.Enroll@bcbssc.com or fax to 803-870-8919. For credentialing status inquiries specifically, email provider.cert@bcbssc.com. For general enrollment questions before submitting, email provider.enrollment@bcbssc.com to confirm required documentation before preparing any paperwork.

Each contact serves a distinct function -- calling 800-868-2510 without saying "Provider Enrollment" at the IVR prompt routes to a general menu that doesn't connect to the enrollment team efficiently.

Using the wrong email for the wrong function (for example, emailing provider.enrollment@bcbssc.com for credentialing status) produces slower responses than using provider.cert@bcbssc.com which is the dedicated credentialing status line.

See BCBS SC official provider contacts -- all phone numbers and emails and BCBS SC Provider Enrollment FAQs -- 800-868-2510 IVR routing, application type guidance, effective date policy for official contact sourcing.

What Is BCBS Called in South Carolina?

In South Carolina, BCBS operates as BlueCross BlueShield of South Carolina -- an independent mutual insurance company established 1946, not owned by Elevance Health, HCSC, or GuideWell -- with its HMO products managed by BlueChoice HealthPlan of South Carolina, its Medicaid MCO product branded as Healthy Blue SC within the SCDHHS South Carolina Healthy Connections program, and its state employees' plan operating as Select Health of South Carolina.

The informal name "South Carolina Blues" refers collectively to BlueCross BlueShield of South Carolina and BlueChoice HealthPlan of South Carolina.

The portal southcarolinablues.com serves both entities -- MyPEP 2.0 at bluecross-sc.my.site.com handles enrollment for commercial BlueCross and BlueChoice products simultaneously, with Healthy Blue SC Medicaid requiring a separate Network Selection in MyPEP and a validated SCDHHS Medicaid ID as a prerequisite.

How to Enroll With BCBS?

To enroll with BCBS SC, log into MyPEP 2.0 at bluecross-sc.my.site.com using Google Chrome, register a new account if this is your first enrollment, select the correct application type from the named options (Enroll a Practitioner, Enroll a Group, Behavioral Health, Autism Provider Panel, Add Virtual Care, or a maintenance action), download the checklist matching your provider type from southcarolinablues.com, submit the Individual Provider Enrollment Application with initials and date on every page to Provider.Blue.Enroll@bcbssc.com or fax 803-870-8919, complete the Adobe Acrobat Sign e-signature using type "Type" not "Image," respond to any missing-item notifications within 21 days, and wait for the welcome notification email confirming your network effective date before seeing any BCBS SC patients.

How to become a provider for bcbs South Carolina involves this complete sequence -- MyPEP at bluecross-sc.my.site.com is the starting point, not any downloadable form.

Becoming a bcbs provider in South Carolina requires the welcome notification before the first patient visit. The contract signature date on the application establishes the network effective date -- not the committee approval date.

How MedSole RCM Manages BCBS SC Provider Enrollment -- From MyPEP 2.0 Navigation Through First Payment in South Carolina

bcbs sc provider enrollment in 2026 requires navigating MyPEP 2.0 on Salesforce Community Cloud at bluecross-sc.my.site.com using Google Chrome, selecting the correct application type from nine named options before a single document is prepared, downloading the correct checklist from three distinct options, submitting with initials and dates on every application page, managing the Adobe Acrobat Sign e-signature using type "Type" not "Image," monitoring the 21-day missing-item cancellation clock, coordinating SCDHHS Medicaid ID NPI assignment for Healthy Blue SC applications, routing behavioral health credentialing through CBA at cba.provrep@companiongroup.com rather than MyPEP, setting up EFT via Provider.EFT@bcbssc.com with a two-to-four-week test period, setting up ERA via EDI.Services@bcbssc.com, and maintaining the 90-day M.D.

Checkup CAA directory validation cycle.

The most common BCBS SC enrollment failures MedSole RCM inherits when taking over applications from practices that attempted internal enrollment: application submitted without initials and dates on every page -- returning a correction notice that starts the 21-day clock.

Behavioral health provider routed through MyPEP instead of CBA -- application returned with no processing progress. Wrong application type selected -- routing the file to an incorrect internal review queue.

And Healthy Blue SC application submitted without a validated SCDHHS Medicaid ID assigned to the NPI -- application rejected with no credentialing progress made.

MedSole RCM manages every BCBS SC enrollment step simultaneously: panel availability confirmed at 800-868-2510 before any documentation begins, correct MyPEP application type identified for every provider category before the portal is opened, Individual Provider Enrollment Application prepared with initials and date on every page before submission to Provider.Blue.Enroll@bcbssc.com, behavioral health providers routed to CBA at cba.provrep@companiongroup.com before a single document is prepared, CAQH ProView completeness verified to BCBS SC's current standard before submission, 21-day missing-item clock monitored with prepared responses before the 7-day notification even arrives, Adobe Acrobat Sign e-signature coordinated with "Type" signature confirmed before the e-sign email is expected, SCDHHS Medicaid ID NPI assignment completed before any Healthy Blue SC application is submitted, EFT initiated through Provider.EFT@bcbssc.com on credentialing approval day, and ERA enrolled through EDI.Services@bcbssc.com before the first BCBS SC claim is submitted.

MedSole RCM charges $99 per payer for bcbs sc provider enrollment -- covering BlueCross BlueShield of South Carolina commercial credentialing, BlueChoice HealthPlan HMO credentialing, Healthy Blue SC Medicaid enrollment, and BlueCross Medicare Advantage participation as separate workflows at the same flat rate.

With a 99 percent first-time approval rate and active relationships across 900 or more payers in all 50 states, MedSole RCM is the most affordable full-service provider enrollment partner for South Carolina healthcare practices.

South Carolina healthcare providers searching for the best credentialing company for BCBS SC commercial enrollment, BlueChoice HealthPlan HMO credentialing, and Healthy Blue SC Medicaid participation will find that MedSole RCM manages all three tracks at $99 per payer -- with MyPEP 2.0 navigation, CBA behavioral health routing, SCDHHS Medicaid ID NPI assignment, 21-day missing-item clock monitoring, and M.D.

Checkup 90-day CAA validation management as standard workflow steps. No credentialing company currently serving South Carolina providers offers lower pricing or deeper BCBS SC-specific enrollment expertise.

The bcbs credentialing process for every specialty in South Carolina follows the same $99 per payer flat rate.

South Carolina practices evaluating best credentialing services for BCBS SC enrollment should confirm the vendor has MyPEP 2.0 experience, CBA credentialing capability for behavioral health, Healthy Blue SC Medicaid ID NPI assignment coordination, and transparent per-payer pricing before selecting a credentialing partner.

When BCBS SC enrollment is complete, South Carolina practices that move their billing to MedSole RCM pay 2.99 percent of collections.

A South Carolina internal medicine practice generating $33,000 monthly in BCBS SC reimbursements pays $986.70 per month for full-service billing at MedSole's rate. At a standard 8 percent billing rate, the same practice pays $2,640 per month.

The annual difference is $19,840.

South Carolina healthcare providers searching for the most affordable credentialing company for BCBS SC commercial, BlueChoice HealthPlan HMO, Healthy Blue SC Medicaid, and BlueCross Medicare Advantage enrollment will find that MedSole RCM's $99 per payer credentialing and 2.99 percent billing is unmatched by any credentialing company or RCM firm currently serving South Carolina providers.

No credentialing company with 900 or more active payer relationships, all-50-state coverage, a 99 percent first-time approval rate, MyPEP 2.0 navigation expertise, and CBA behavioral health credentialing coordination offers lower pricing for bcbs sc provider enrollment.

Whether your South Carolina practice is starting initial BCBS SC commercial enrollment through MyPEP 2.0, routing behavioral health credentialing to CBA, completing the SCDHHS Medicaid ID NPI assignment for Healthy Blue SC, managing the 90-day M.D.

Checkup CAA validation cycle, or responding to a 21-day missing-item notification, MedSole RCM handles every step at the same flat $99 per payer rate. Start your BCBS SC enrollment with MedSole RCM today.

The medical billing service that follows BCBS SC enrollment at MedSole's 2.99 percent rate covers BlueCross BlueShield of South Carolina commercial claims, BlueChoice HealthPlan HMO claims, Healthy Blue SC Medicaid claims, and BlueCross Medicare Advantage claims in one coordinated South Carolina billing workflow -- with BlueCard coordination for out-of-state BCBS members who receive care at South Carolina practices.

BCBS SC Provider Enrollment: Six Additional Questions From South Carolina Healthcare Providers

How Do I Track My BCBS SC Provider Enrollment Application Status?

Track your BCBS SC enrollment application by logging into MyPEP 2.0 at bluecross-sc.my.site.com using Google Chrome and navigating to Applications, then My In-Progress Applications, where the Status column shows your current application status: In Progress, Submitted, Awaiting Signature, or Awaiting Provider Response.

If the application enters "Awaiting Provider Response" status, BCBS SC sends missing-item notifications every 7 days for a maximum of 21 days -- after which the application is canceled if missing items aren't received.

For direct bcbs credentialing status inquiry, email provider.cert@bcbssc.com or call 800-868-2510 and say "Provider Enrollment" when prompted.

Practices that submitted through MyPEP and haven't received a welcome notification after 90 days from complete submission should email provider.cert@bcbssc.com rather than calling -- the dedicated email produces faster credentialing status responses than the general phone queue for status-only inquiries.

Is There a BCBS SC Provider Enrollment Form I Can Download?

BCBS SC offers two provider enrollment documents -- the Individual Provider Enrollment Application PDF at provider.bcbssc.com (for physicians, NPs, PAs, and individual practitioners, submitted to Provider.Blue.Enroll@bcbssc.com or faxed to 803-870-8919 with initials and date on every page) and the MyPEP 2.0 portal at bluecross-sc.my.site.com where all applications are formally submitted and tracked.

See the BCBS SC Individual Provider Enrollment Application -- initials and date required, Provider.Blue.Enroll@bcbssc.com submission for the current application PDF.

The downloadable form PDF is a documentation preparation tool -- the official enrollment submission is completed through MyPEP 2.0, not by submitting the PDF alone. Neither the physician PDF nor the WebCVO-equivalent facility application is Step 1. MyPEP registration and application type selection come first.

What Is the Most Affordable BCBS SC Provider Enrollment Service?

MedSole RCM provides complete BCBS SC provider enrollment -- including BlueCross BlueShield of South Carolina commercial credentialing and BlueChoice HealthPlan HMO credentialing simultaneously, Healthy Blue SC Medicaid enrollment with SCDHHS Medicaid ID NPI assignment coordination, MyPEP 2.0 application type navigation, CBA behavioral health routing for mental health and substance abuse providers, 21-day missing-item clock monitoring, and M.D.

Checkup 90-day CAA directory validation management -- at $99 per payer with a 99 percent first-time approval rate across 900 or more active payers in all 50 states.

Medical billing starts at 2.99 percent of collections after enrollment is confirmed. No other full-service credentialing company with comparable BCBS SC-specific expertise offers lower pricing.

Our credentialing bcbs experience covers every provider type and every BCBS SC product line at the same flat $99 per payer rate.

Do Behavioral Health Providers in South Carolina Need to Credential With BCBS SC Differently?

Yes -- mental health and substance abuse providers credentialing with BCBS SC must contact CBA (Companion Benefit Alternatives) at cba.provrep@companiongroup.com rather than submitting through MyPEP 2.0, because CBA is an independent company that administers behavioral health benefits on behalf of BlueChoice HealthPlan and covers both the BlueChoice commercial network and the CBA-administered mental health network simultaneously.

Submitting through MyPEP as a behavioral health provider will result in the application being returned. Blue cross blue shield credentialing for behavioral health in South Carolina routes through CBA, not the standard individual practitioner MyPEP pathway.

Licensed therapists and licensed counselors in South Carolina credentialing through CBA should review our best credentialing services for mental health providers guide for the evaluation criteria that matter most for South Carolina behavioral health-specific credentialing.

How Long Does BCBS SC Credentialing Take in 2026?

BCBS SC credentialing takes 60 to 90 days from complete application submission -- where "complete" means MyPEP 2.0 was accessed using Google Chrome, the correct application type was selected, CAQH ProView is in complete and attested status, the Individual Provider Enrollment Application has initials and date on every page, the Adobe Acrobat Sign e-signature used type "Type" not "Image," and no missing-item notifications have gone unanswered past the 21-day cancellation window.

The network effective date begins from the contract signature date on the application and is not retroactive.

Getting credentialed with bcbs South Carolina faster than 60 days is possible but uncommon.

How to become a provider for bcbs South Carolina in the shortest timeline requires CAQH ProView completeness before submission, correct application type selection before the portal is opened, and an Adobe Acrobat Sign "Type" signature the first time.

Any single item missed restarts the clock.

What Is MyPEP for BCBS SC?

MyPEP -- My Provider Enrollment Portal -- is BlueCross BlueShield of South Carolina's official provider enrollment portal, launched April 4, 2022 -- BCBS SC implemented My Provider Enrollment Portal (MyPEP) and upgraded to MyPEP 2.0 in June 2025, accessible at bluecross-sc.my.site.com using Google Chrome, built on Salesforce Community Cloud infrastructure, and serving as the one-stop shop for all new enrollment applications (Practitioner, Group, Behavioral Health, Autism Provider Panel, Add Virtual Care), maintenance requests (address changes, satellite location additions, practitioner additions or removals), and status tracking for all applications in progress.

The mypep system replaced all prior fax and email enrollment pathways on April 4, 2022. The June 2025 mypep 2.0 upgrade added the current navigation structure, updated application type routing, and the January 2026 User Manual revision.

The Salesforce Community Cloud platform explains the my.site.com domain and the Google Chrome recommendation -- the platform performs optimally on Chrome, and non-Chrome browser submissions may corrupt the application file on BCBS SC's end.

MedSole RCM treats bcbs sc provider enrollment as step one of a complete revenue cycle management workflow -- MyPEP 2.0 application type selection, CAQH ProView completeness verification, CBA behavioral health routing, 21-day missing-item clock management, Adobe Acrobat Sign e-signature coordination, EFT via Provider.EFT@bcbssc.com, ERA via EDI.Services@bcbssc.com, 90-day M.D.

Checkup CAA validation, and billing all connected to the same South Carolina provider file at 2.99 percent of collections. See our complete provider enrollment and credentialing services for South Carolina at $99 per payer.

All BlueCross BlueShield of South Carolina provider enrollment information in this article is sourced from the MyPEP 2.0 User Manual (Revised January 2026), the M.D. Checkup User Guide (Revised August 2025), the BCBS SC Provider Enrollment FAQs from southcarolinablues.com, the April 4, 2022 new provider enrollment process announcement from member.bluechoicesc.com, the Healthy Blue SC Provider Administrative Office Manual, the SCDHHS MCO provider directory, the official BCBS SC Join Our Networks page at southcarolinablues.com, and the Individual Provider Enrollment Application (June 2023 version). Enrollment requirements are subject to change with each quarterly BCBS SC bulletin cycle. Verify all current credentialing requirements by calling 800-868-2510, saying "Provider Enrollment" when the IVR prompts, and emailing provider.enrollment@bcbssc.com before preparing any documentation.